| Pair Name | Plumbagin, Zoledronic acid | ||
| Phytochemical Name | Plumbagin (PubChem CID: 10205 ) | ||
| Anticancer drug Name | Zoledronic acid (PubChem CID: 68740 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Plumbagin, Zoledronic acid | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | BCL2 | hsa596 |
| Up-regulation | Expression | NOTCH1 | hsa4851 | |
| In Vitro Model | MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 |
| Result | Combination of ZA and PL synergistically suppresses human breast cancer MDA-MB-231SArfp cells in vitro. PL can inhibit ZA-induced activation of the Notch-1 signaling pathway and subsequently reduce the expression of Bcl-2, thus potentiating cancer cell apoptosis. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Synergistic suppression of human breast cancer cells by combination of plumbagin and zoledronic acid In vitro. Acta Pharmacol Sin. 2015 Sep;36(9):1085-98. doi: 10.1038/aps.2015.42. Epub 2015 Aug 3. Erratum in: Acta Pharmacol Sin. 2019 Aug;40(8):1127-1128. | Click |
